Sinclair Institute the Art of Oral Loving Video on Line
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|---|---|
| Nama sistematis (IUPAC) | |
| (1R,3S)- 5-[2-[(1R,3aR,7aS)-1- [(2R)-6-hydroxy-half dozen-methyl-heptan-2-yl]- 7a-methyl-ii,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]- 4-methylidene-cyclohexane-one,three-diol | |
| Data klinis | |
| Kat. kehamilan | B3 (Au), C (U.South.) |
| Status hukum | S4 (Au), POM (United kingdom) |
| Rute | Oral, 4, topical |
| Information farmakokinetik | |
| Metabolisme | Renal |
| Waktu paruh | 5–8 hours |
| Ekskresi | Renal |
| Pengenal | |
| Nomor CAS | 32222-06-iii |
| Kode ATC | A11CC04 D05AX03 |
| PubChem | CID 134070 |
| DrugBank | APRD00246 |
| ChemSpider | 4941667 |
| UNII | FXC9231JVH  Y |
| Data kimia | |
| Rumus | C 27 H 44 O three |
| Massa mol. | 416.64 grand/mol |
| SMILES | eMolecules & PubChem |
Kalsitriol (bahasa Inggris: 1,25-dihydroxycholecalciferol, i,25-dihydroxyvitamin D3, 1,25-(OH)twoD3 ) adalah hormon pleitrofik yang merupakan bentuk aktif vitamin D setelah proses konversi oleh ginjal,[one] terhadap kalsidiol yang disekresi oleh hati,[ii] dengan katalis berupa enzim sitokrom P450 hidroksilase one-alfa.[3]
Kalsitriol memiliki sifat anti-proliferatif, pro-apoptotik dan pro-diferensiasi terhadap berbagai jenis sel tubuh, dan sifat anti-kanker, seperti kanker prostat, kanker usus besar,[4] kanker indung telur, kanker payudara, leukemia,[5] oleh kapasitas regulasi terhadap metabolisme kalsium dan fosfat,[half-dozen] [7] serta modulasi sistem kekebalan dan fungsi sistem saraf pusat.[four]
Kalsitriol akan dikonversi menjadi asam kalsitroat sebelum diekskresi melalui empedu,[8] atau urin.[9]
Rujukan [sunting | sunting sumber]
- ^ (Inggris) "Analysis of SNPs and Haplotypes in Vitamin D Pathway Genes and Renal Cancer Take a chance". Core Genotyping Facility at the Advanced Engineering Center of the National Cancer Constitute, Segmentation of Cancer Epidemiology and Genetics, National Cancer Found, National Institutes of Health (NIH), Department of Health and Human Services, International Agency for Research on Cancer, Section of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Plant of Public Wellness, Establish of Carcinogenesis, Cancer Research Centre, Department of Preventive Medicine, Faculty of Medicine, Palacky University, Found of Hygiene and Epidemiology, Beginning Faculty of Medicine, Charles University, Department of Epidemiology, Institute of Occupational Medicine, Ohio Land Academy Medical Center; Sara Karami, Paul Brennan, Philip S. Rosenberg, Marie Navratilova, Dana Mates, David Zaridze, Vladimir Janout, Helena Kollarova, Vladimir Bencko, Vsevolod Matveev, Neonila Szeszenia-Dabrowska, Ivana Holcatova, Meredith Yeager, Stephen Chanock, Idan Menashe, Nathaniel Rothman, Wong-Ho Chow, Paolo Boffetta, dan Lee E. Moore . Diakses tanggal 2010-12-10 .
- ^ (Inggris) "Vitamin D Deficiency and Liver Disease". Medicine Medical Director of Liver Transplantation University of Tennessee Wellness Science Center; Satheesh Nair . Diakses tanggal 2010-12-10 .
The liver produces 25-hydroxy (25-OH) vitamin D, also known as calcidiol, the immediate precursor to the metabolically active ane,25 dihydroxyvitamin D 1-25 vitamin D, too known as calcitriol.
- ^ (Inggris) "Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the man kidney". Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital;Zehnder D, Banal R, Walker EA, Bradwell AR, Howie AJ, Hewison Grand, Stewart PM . Diakses tanggal 2010-12-10 .
- ^ a b (Inggris) "The pleiotropic deportment of vitamin D". Department of Physiology, McGill University; Lin R, White JH . Diakses tanggal 2010-12-x .
- ^ (Inggris) "Vitamin D and Human Wellness: Lessons from Vitamin D Receptor Null Mice". Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Massachusetts General Infirmary, Endocrine Unit; Roger Bouillon, Geert Carmeliet, Lieve Verlinden, Evelyne van Etten, Annemieke Verstuyf, Hilary F. Luderer, Liesbet Lieben, Chantal Mathieu, dan Marie Demay . Diakses tanggal 2010-12-ten .
To proceeds more than insight into the antiproliferative and prodifferentiating effect of i,25-(OH)2D, genomic profiling has been performed in malignant cells such every bit prostate (127,128,129,130,131,132,133), chest (134,135,136), leukemia (137,138), colon (139), and ovarian cancer (140) cells, and squamous cell carcinoma cells (141). Since and then, the antineoplastic activeness of ane,25-(OH)2D was shown both in vitro and in vivo in a wide variety of malignancies, such as leukemia (266,267) and colon (268,269), breast (270,271,272), and prostate cancer (273,274).
- ^ (Inggris) "Vitamin D and cancer: an update of in vitro and in vivo information". Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid; Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A . Diakses tanggal 2010-12-10 .
- ^ (Inggris) "Vitamin D and colon carcinogenesis". UCLA Center for Human Nutrition, Academy of California at Los Angeles; Harris DM, Go VL . Diakses tanggal 2010-12-10 .
- ^ (Inggris) "Target prison cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid, Evidence for a pathway in kidney and bone involving 24-oxidation" (PDF). Department of Biochemistry, Queen'due south University, Homo Nutrition Research Center on Aging, Tufts University; Guy MAKIN, David LOHNES, Valarie BYFORD, Rahul RAY dan Glenville JONES . Diakses tanggal 2010-12-10 .
- ^ (Inggris) "Vitamin D Metabolism: New Concepts and Clinical Implications". Hanson Institute, Adelaide, SA 5000 and Schoolhouse of Molecular and Biomedical Science, University of Adelaide; PH Anderson, BK May, dan HA Morris . Diakses tanggal 2010-12-ten .
Source: https://id.wikipedia.org/wiki/Kalsitriol
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